Sodium lauryl sulfate (SLS) is the sodium salt of lauryl sulfate. It is an inexpensive surfactant that foams easily and is an excellent detergent. ChemSpider ID 8677. Opinion | What Does the Recent Pig-to-Human Kidney Transplant Mean for Tissue Therapeutics? This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. So what does this ingredient do, why is it in everything, and what does the evidence say about how safe it is? Researchers from Germany tested 1,600 patients for SLS irritancy and found 42% of the patients tested had an irritant reaction. Examples of the different uses in various products are shown in the table below: Sodium lauryl sulfate has been used in pharmaceutical and personal care products for several decades. It may also be called sodium dodecyl sulfate; dodecyl sulfate, sodium salt; and sodium n-dodecyl sulfate. In a pioneering procedure, a team of surgeons at New York University Langone Health Grossman School of Medicine in New lepopup_add_event("onexit", { In 2003, the US Department of Health and Human Services evaluated the safety of SLS concluding that SLS is safe for use in oral care products2. Cable, A. American Pharmacists, Handbook of pharmaceutical excipients, 2017. 121CFR 172.822 2Tentative Final Monograph 21CFR 356 376/768/EEC, Privacy Policy Terms of Sale Terms of Use Children's Privacy Policy Cookie Policy Cookie Consent Tool. http://www.mayoclinic.com/health/canker-sore/DS00354/DSECTION=causes. The SLS Toms of Maine uses is entirely derived from the vegetable sources of coconut and/or palm kernel oil. When we use a wash or beauty product on our skin, its probably a liquid made of a water phase and an oily phase. Working Hours (Mon to Friday): 08:30 - 17:30. Of all the ingredients we use, Toms of Maine tends to receive the highest volume of questions about our use of SLS. However, for consumers who prefer to use a product without SLS, we offer some SLS-free alternatives. Sodium lauryl sulfate can interact with cationic surfactants, leading to decreased activity. It is used in industrial strength degreasers, floor cleaners, bubble bath and toothpastes. It is also GRAS listed and included in the FDA Inactive Ingredients Database. No express or implied warranty is made for specific properties or fitness for any particular application or purpose. Therefore, solutions should be used soon after preparation and/or not be exposed to extreme conditions. Some material is published to support research and user education, and for the public good. Many of these ingredients would not be considered by Toms of Maine because they fail to meet our Stewardship Model guidelines. Acetaminophen and Codeine Phosphate 300 mg / 30 mg, Acetaminophen and Hydrocodone Bitartrate 325 mg / 7.5 mg, Acetaminophen and Hydrocodone Bitartrate 325 mg / 5 mg, CIR publication (1983). Accessed on August 30, 2011. SLS ticks both of these boxes. As with any product, be sure to discontinue use if you experience discomfort or other indications that the product may not be appropriate for your individual body chemistry. Cook, C.G. It is used in industrial strength degreasers, floor cleaners, bubble bath and toothpastes. The sodium lauryl sulfate formula is a highly effective anionic surfactant used to remove oily stains and residues. Yousuf Mohammed receives funding from the U.S. Food and Drug Administration through grants 01FD005226,U01FD006946 and U01FD006700. http://ijt.sagepub.com/content/2/7/127. And some surfactants are more irritating to our skin than others. It has a smooth, slippery (soapy) feel when rubbed between fingers and a perceptible odour of lipids. So authorities dont ban its use, but instead cap the maximum percentage at which it can be used in products. What are hives, the common skin condition that gives you itchy, red bumps? SLS is approved for use as a direct additive to food by the United States Food and Drug Administration (FDA) when used as a surfactant, whipping and wetting agent or as an emulsifier1. So SLES is an oligomer that contains a few ethylene oxide linkages; the mean quantity is about 3, as shown in the 3-D image. When handling the material, workers should observe standard SHEQ protocols in line with the circumstances and quantity of material being processed. We use SLS in many of our products because of its long history of safe and effective use, and because of the volume of scientific substantiation for its safety. Using a chemical that weakens this defence mechanism can potentially cause our skin harm. All information is provided in good faith to enable collaboration and sharing of know-how among our community of users. Sodium lauryl sulfate is prepared by reacting sulfuric acid with lauryl alcohol, followed with the addition of sodium carbonate to produce sodium lauryl sulfate. It is used in solid dosage forms and topical products largely due to its surface-active properties. The lauryl alcohol is then combined with sulfur which then forms the salt, sodium lauryl sulfate. Alternately, the whole oil can be esterified and then hydrogenated to form the fatty alcohols of which lauryl alcohol would be isolated by fractionation. Sodium Lauryl Sulfate also referred to as Sodium laurilsulfate or Sodium dodecyl sulfate is a synthetic organic compound widely used in personal care products as an anionic surfactant. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Sodium lauryl sulfate has not been shown to be carcinogenic (cancer-causing) when either applied directly to the skin or consumed. Its also important to note theres no scientific evidence SLS causes cancer, despite what you may read on the internet. Sodium lauryl sulfate is a surfactant, which means a molecule that has ampiphilic properties. Sodium laureth sulfate (SLES), an accepted contraction of sodium lauryl ether sulfate (SLES), also called sodium alkylethersulfate, is an anionic detergent and surfactant found in many personal care products (soaps, shampoos, toothpaste, etc.) Sodium lauryl sulfate is frequently confused with sodium laureth sulfate, but the two are distinct . Sodium lauryl sulfate is an approved pharmaceutical excipient and is listed in all the major pharmacopoeia. In the pharmaceutical industry, it has been used as an excipient in dissolvable dosage forms. Lauryl ether sulfate sodium | C24H50Na2O5S | CID 21889068 - structure, chemical names, physical and chemical properties, classification, patents, literature . The lauric acid is isolated and then hydrogenated to form the lauryl alcohol. Sodium Lauryl Ether Sulfate [SLES] is a low-cost and very effective for emulsifying, wetting, cleaning, foaming and solubilizing, good biodegradation, with wide compatibility, good solvency. Sodium Lauryl Sulfate (also referred to as Sodium laurilsulfate or Sodium dodecyl sulfate) is a synthetic organic compound widely used as an excipient and in personal care products as an anionic surfactant. Sodium laureth sulfate | C14H29NaO5S | CID 23665884 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . Learn more about what it is, why it is used, and if it is safe to use it. In fact, SLS is so known to cause irritation, its used as a positive control in dermatological testing. [3] G. Heinicke, J.B. Schwartz, The influence of surfactants and additives on drug release from a cationic Eudragit coated multiparticulate diltiazem formulation, Pharm Dev Technol, 12 (2007) 381-389. While an approved excipient, Sodium lauryl sulfate is fairly harmful and acutely irritant to mucous membranes (eyes, upper respiratory tract and stomach). Sodium lauryl sulfate (SLS) is found in shampoos, soaps, various beauty and cleaning products, and even some foods. Due to the inherent risks, the bulk material should be stored in a well-closed container away from strong oxidizing agents in a cool, dry place. Sodium lauryl sulfate is used in a variety of products, and has a long history of safe use. Read more: Excipient (pharmacologically inactive substance). In formulated products, Sodium lauryl sulfate is incompatible with salts of polyvalent metal ions (e.g Aluminium, Zinc, and Magnesium). PharmaCentral 2021 . PharmaCentral.com does not make any representation or warranty of any kind regarding its accuracy, adequacy, or legality. A surfactant allows the oil and water molecules to bind together its whats found in soaps and detergents so we can wash our oily faces or dishes with water and get the grime to disappear. Health Check: what should I eat to improve my skin? mode: "every-time", Your toothpaste, shampoo and body wash probably all contain SLS. It has to have been found in studies to irritate human skin, and it has to have the ability to penetrate the skin. All respective intellectual property, such as trademarks and logos, are properties of their owners. Some information contained on PharmaCentral.com may contain copyrighted material, the use of which may not have been specifically authorised by the respective copyright owners. It is also known by the term sodium dodecyl sulfate. Accessed on August 30, 2011, The Mayo Clinic. Inhalation of Sodium lauryl sulfate has the potential to damage respiratory tract tissue, and should therefore be avoided. That is, new products being tested to see how irritating they might be to human skin are compared to SLS - something we know definitely to be irritating. SLES, sodium lauryl sulfate (SLS), ammonium lauryl sulfate (ALS), and . F. Zhao, V. Malayev, V. Rao, M. Hussain, Effect of sodium lauryl sulfate in dissolution media on dissolution of hard gelatin capsule shells, Pharm Res, 21 (2004) 144-148. Skin care products also have hotline numbers on the packaging that can be contacted to report adverse effects. Available for Android and iOS devices. [1] C. Arias, I. Gmez-Escalonilla, C. Rueda, C. Molina, Influence of the purification of sodium dodecyl sulfate on the physical properties of solutions and O/W emulsions, Drug Dev Ind Pharm, 24 (1998) 95-100. Sodium lauryl sulfate is widely used as an anionic surfactant, detergent, emulsifying agent, skin penetrant, tablet and capsule lubricant and wetting agent. Copyright 20102022, The Conversation Media Group Ltd. This can happen even when the concentrations of either species are very low. food particles). Pharmacopoeial Compliance: USP-NF; Ph.Eur; B.P; J.P; I.P, Synonyms and Trade Names: Sodium Lauryl Sulphate; Sodium Lauryl Sulfate; SLS; Sodium Dodecyl Sulfate; SDS; Dodecyl Alcohol Hydrogen Sulfate, Sodium Salt Dodecyl Sulfate; Lauryl Sodium sulfate; Lauryl Sulfate, Sodium Salt; Monododecyl Sodium Sulfate; Sodium Dodecyl Sulfate; Sodium n-dodecyl Sulfate; Sodium Laurilsulfate; Sodium Monododecyl Sulfate; Sulfuric Acid Monododecyl Ester, Sodium Salt; Texapon KI2P; Elfan 240, Uses: Ionic Surfactant; Tablet Lubricant; Solubiliser; and Dissolution Rate Enhancer. Average mass 288.379 Da. Many other surfactants agents exist, including synthetic alternatives and additional naturally derived ones. International Journal of Toxicology 2 (7): 12781. It's essentially a synthetic soap. and for industrial uses.SLES is an inexpensive and very effective foaming agent. University of Queensland provides funding as a member of The Conversation AU. This may partly be fueled by the volume of misinformation currently available on the internet. }); PharmaCentral.com may on occasion publish user-generated content. It typically appears as a white or cream colored crystal or powder. [1] Sodium lauryl sulfate has also been implicated in causing canker sores, often from use of toothpaste or mouthwashes that contain this ingredient.[2]. As we know, oil and water dont mix, so something is required to keep the ingredients together. Sodium lauryl sulfate is frequently used as a surfactant, or foaming agent. In many of our toothpastes SLS is used as a surfactant and helps to properly disperse the ingredients during brushing, and ensures easy rinsing and removal of debris (i.e. It has a perceptible lipid odour. Health Check: what should I eat to improve my skin? This cap varies based on how long the product is likely to be in contact with the skin. positive control in dermatological testing. . The oils can be split into glycerin and the component fatty acids, one of which is lauric acid. That something is called a surfactant. LD50 (rat, oral): 1.29 g/kg. So on products containing SLS, you should see something like if this product causes any skin redness or irritation, discontinue use and consult a medical practitioner. Oh no! Sodium lauryl sulfate (SLS) is the sodium salt of lauryl sulfate. It is a negatively charged surfactant and one of the most detergents in personal and household products. This means the sulfate head group (shown by the pink shading in the diagram below) is hydrophilic and water soluble, while the 12-carbon-long chain is hydrophobic and water insoluble. Data sources include IBM Watson Micromedex (updated 1 Nov 2022), Cerner Multum (updated 25 Oct 2022), ASHP (updated 12 Oct 2022) and others. Our Botanically Bright and Botanically Fresh toothpastes use our best performing SLS alternative, a blend of Sodium Cocoyl Glutamate and Lauryl glucoside, which are other naturally derived dispersants from coconut or palm kernel oil and corn. So products that will be on the skin for a prolonged time can contain no more than 0.05-2.5% SLS in most countries. Sodium lauryl sulfate (C12H25SO4Na) is a surface-active agent used in cleaning and cosmetic products. We comply with the HONcode standard for trustworthy health information. It may also be used to aid the dissolution rate of poorly soluble active substances during dissolution test measurements. If sodium lauryl sulfate is left in contact with human skin and not washed immediately, concentrations should not exceed one percent. It may also be called sodium dodecyl sulfate; dodecyl sulfate, sodium salt; and sodium n-dodecyl sulfate. Use of eye protection, gloves, and other suitable PPE are advised. [2] J. Hanaee, Y. Javadzadeh, S. Taftachi, D. Farid, A. Nokhodchi, The role of various surfactants on the release of salbutamol from suppositories, Farmaco, 59 (2004) 903-906. In solution, Sodium lauryl sulfate may undergo hydrolysis to lauryl alcohol and sodium bisulfate when pH falls significantly (e.g < pH 2). Another study found the warmer the water used with SLS, the more irritating it will be. It is found in high concentrations in industrial products, including engine degreasers, floor cleaners, and car wash products, where workplace protections can be implemented to avoid unsafe exposures. It is supplied as white or whitish-coloured crystals, powder or flaky material, with a slippery feel upon rubbing between fingers. People with a history of sensitive skin, hyperirritable skin and patients suffering from skin conditions such as atopic dermatitis (eczema), rosacea and psoriasis are best to avoid products containing SLS. In the pharmaceutical industry, it has been used as an excipient in dissolvable dosage forms. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. period: 24 If youve ever Googled the causes of a skin complaint or damaged hair, chances are someone on the internet has pointed the finger at SLS, or sodium lauryl (or laureth) sulfate, a common ingredient in beauty products, washes, toothpastes and even cleaning products. Our Stewardship Model guides us to select ingredients which have been processed in a manner that supports our philosophy of human and environmental health. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Sodium lauryl sulfate is a fairly stable excipient under standard storage conditions. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. *All claims in respect to the conformity are subject to our Terms and Conditions. Toms of Maine recognizes that no two people are alike, and even with naturally derived ingredients, some individuals may develop an allergic reaction that is unique to them. This may partly be fueled by the volume of misinformation currently available on the internet. All rights reserved. Under Section 107 of the Copyright Act 1976, allowance is made for Fair Use for purposes such as criticism, comment, news, reporting, scholarship, education, and research. It may also serve as an emulsifier, helping oil based and water based ingredients to stay mixed. Medically reviewed by Drugs.com. SLS is approved for use as a direct additive to food by the United States Food and Drug Administration (FDA) when used as a surfactant, whipping and wetting agent or as an emulsifier. - Charge. Molecular Formula CHNaOS. Our skins outermost layer is specially designed to keep harmful stuff out, and this is where a surfactant can cause problems. Any information provided on our platform is for general informational and educational purposes only. All consumer and cosmetic product manufacturers are required to conduct thorough testing and include any adverse findings in the form of warnings on their labels. SLES is the most common of a group of commercial sodium and ammonium alkyl and alkyl ether sulfates. Sodium lauryl sulfate is a surfactant, and its efficacy, low cost, abundance and simplicity mean it's used in a variety of cosmetic, dermatological and consumer products. It is similarly used in pharmaceutical products taking advantage of its surfactancy properties. Sodium lauryl sulfate is used in a variety of products, and has a long history of safe use. Consult the MSDS for more detailed information. Sodium lauryl sulfate (C12H25SO4Na) is a surface-active agent used in cleaning and cosmetic products.
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